What does the Supremacy Clause state about state laws in relation to the US Constitution?

The Supremacy Clause, found in Article VI, Clause 2 of the United States Constitution, establishes that the Constitution and federal laws made pursuant to it are the supreme law of the land. This means that when there is a conflict between state laws and federal laws, federal law prevails. Therefore, state laws must adhere to federal law and the Constitution. If a state law contradicts a federal law, the federal law takes precedence, and the state law may be invalidated. This framework is crucial for maintaining a cohesive legal system across the United States, ensuring that all states operate within the parameters set by the Constitution and federal statutes.